Seeking Clues to Transplantation Tolerance

Challenges to achieving clinical transplantation tolerance.

Clinical transplantation tolerance: many rivers to cross.

Modern immunosuppressive regimens for organ transplantation have resulted in excellent short-term results but less dramatic improvements in long-term outcomes. Moreover, they are associated with significant deleterious effects. One solution that should avoid the adverse drug effects and result in improved graft and patient longevity as well as positively impacting on the organ shortage is the e...

Seeking for Clues about Users' Information Needs in Their Navigation

Adaptive navigation systems are tools intended to assist users when they search the Web. Thus, they often have to know the users ' current information needs (IN). However, they suffer from the lack of information available about users' IN and the lack of user feedbacks. Accordingly, they have to seek for clues about users ' IN in their navigation behaviours. This paper puts forward a method tha...

Tolerance in Kidney Transplantation

Advances in immunosuppressive treatments led us to better control acute rejection and improve graft survival in organ transplantation. However, immunosuppressive drugs, due to their toxicity, are also responsible for many side effects as opportunistic infections, renal failure, cardiovascular disease and malignancy (Stegall et al, 1997; Soulillou et al, 2001; Ojo et al, 2003; Fishman et al, 200...

Tregs and transplantation tolerance.

The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes specific unresponsiveness to donor alloantigens. ...